When off is the second element in a phrasal verb, eg get off, keep off, take off, look up the verb. When it is part of a set combination, eg off duty/work, far off, look up the other word.
The adverb off means away or distant. You might run off from the dinner table after an argument with your family about what to watch on TV later. You might dash off, moving away from where
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The suffix - off is used to denote a competition, specifically a final match between two contestants. It is occasionally used in informal terms, especially in sports.